| # | Spieler | Team | GP | TOT | SACK | INT | FF |
|---|---|---|---|---|---|---|---|
| 1 | TB Terrel Bernard | Bills | 12 | 65 | 0.0 | — | — |
| 2 | DW Dorian Williams | Bills | 16 | 63 | 0.0 | — | — |
| 3 | BC Bradley Chubb | Bills | 17 | 47 | 8.5 | — | — |
| 4 | GR Greg Rousseau | Bills | 16 | 46 | 7.0 | — | — |
| 5 | JA Joe Andreessen | Bills | 17 | 35 | 0.0 | — | — |
| 6 | DF Demetrius Flannigan-Fowles | Bills | 10 | 33 | 1.0 | — | — |
| 7 | JS Javon Solomon | Bills | 17 | 17 | 1.0 | — | — |
| 8 | KJ Keonta Jenkins | Bills | 3 | 9 | 0.0 | — | — |
| 9 | JC Jimmy Ciarlo | Bills | 1 | — | — | — | — |